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About Me

  • Personal information

      • Name
      • Hemanta K. Majumder,
        Ph.D., FNA, FASc, FNASc, FAScT, FTWAS
      • Telephone
      • (033) 2499 5727(O), (033) 2359 1532(R)
        Fax:(033) 2473 5197
      • Email
      • hkmajumder@iicb.res.in (O),
        hemantamajumder@yahoo.co.in
        hkmajumder2@gmail.com
      • Date of birth
      • 05/05/1950
      • Sex
      • Male
      • Marital Status
      • Married
      • Spouse’ Name
      • Chaitali Majumder
      • Daughters’ Name
      • Dr. Parijat Majumder (Lahiri),
        Dr. Rupamanjari Majumder (Banerjee)
  • Designation

    NASI-Senior Scientist Platinum Jubilee Fellow
    Sir J. C. Bose National Fellow (DST) Ex-Raja Ramanna Fellow (DAE) Former Head, Infectious Diseases & Immunology Division CSIR-Indian Institute of Chemical Biology, Kolkata 700 032

    Adjunct Professor
    Department of Biophysics, Molecular Biology and Bioinformatics University of Calcutta

    Former Working Chairman (2004 – 2011)
    West Bengal State Council of Science & Technology Bikash Bhawan, Salt Lake, Kolkata

Education

M.Sc., Biochemistry

Calcutta University, Kolkata

Year : 1970

Ph.D,Biochemistry

Bose Institute(Calcutta University),Kolkata

Year : 1975

Post Doctorate

Albert Einstein College of Medicine, New York

Year : 1976-1979

Post Doctorate

University of Zurich, Switzerland

Year : 1979-1981

Scientist ‘C’

Indian Institute of Chemical Biology, Kolkata

Year : 1982

Scientist ‘E1’

Indian Institute of Chemical Biology, Kolkata

Year : 1987

Visiting Scientist

University of California,Berkeley

Year : 1988-1990

Scientist ‘E2’

Indian Institute of Chemical Biology, Kolkata

Year : 1990

Scientist ‘F’

Indian Institute of Chemical Biology, Kolkata

Year : 1995

Scientist ‘G’

Indian Institute of Chemical Biology, Kolkata

Year : 2000-2012

Raja Ramanna Fellow (DAE)

Indian Institute of Chemical Biology, Kolkata

Year : 2012-2016

NASI-Senior Scientist Platinum Jubilee Fellow

Indian Institute of Chemical Biology, Kolkata

Year : 2016- till date

Membership of Professional bodies, Technical committees:

I. Fellow of The World Academy of Sciences (FTWAS)

II. Elected Fellow of the Indian National Science Academy (FNA)

III. Elected Fellow of the Indian Academy of Sciences (FASc)

IV. Fellow of the National Academy of Sciences (FNASc), India

V. Fellow of the Academy of Science & Technology (FAScT), W. B.

VI. Indian Science Congress Association (ISCA) (life Member)

VII. Guha Research Conference (GRC) Elected Member

VIII. Society of Biological Chemists (SBC-1) Life Member/Ex Vice President

IX. Association for DNA finger printing & Technology (Life Member)

X. Indian Society for Cell Biology (ISCB) (Life Member)

XI. Administrative Staff College of India (ASCI) (Life Member)

XII. Member of the Research Advisory Council Vector Control Research Center, Pondicherry (2005 – 2009)

XIII. Member of the Senate of IISER Kolkata (2010 -2013)

XIV. Member of the Bio Safety Committee of Calcutta University

XV. Chairman of the Institutional Ethics Committee, Institute of Post Graduate Medical Education & Research (IPGMER), Kolkata

XVI. Member of the Selection Committee for Scholarships to the High School and Under Graduate students under Kishore Vaigyanik Protsahan Yojana (KVPY) sponsored by DST, Govt. of India for year 2000-2003

XVII. Member of the Question Bank Committee of KVPY 2005

XVIII. Member of the Board of Studies in Biotechnology, St. Xaviers College, Kolkata

XIX. Member of the Board of Studies in Microbiology, Lady Brabourne college, Kolkata

XX. Member of the Selection Committee for Senior Research Fellow (SRF) and Research Associate (RA) in Section Life Science- 12 of HRD of CSIR, New Delhi

XXI. Member of the “Technical Screening Committee of Small Business Innovation Research Initiative (SBIRI), Department of Biotechnology (DBT), Govt. of India. (2008-2010).

XXII. Member of the Infectious Disease Biology Task Force (IDBTF) of DBT, Govt. of India (2012-2015).

XXIII. Member of the Research Advisory Committee of the Central Sericulture Research & Training Institute, Berhampur, Murshidabad, West Bengal.

XXIV. Working Chairman, West Bengal State Council of Science and Technology ( WBSCST) (2004-2011)

XXV. Chairman, Expert Committee for State Innovation Award, Govt. of West Bengal (2004-2011).

XXVI. Chairman, State Level Climatic Change Committee, Govt. of West Bengal (2006-2011).

XXVII. Chairman, Local Chapter of National Academy of Sciences, India (2009-present)

XXVIII. Convener, Local Chapter of Indian National Science Academy (2012-present)

XXIX. Member, Board of Studies, Assam University, Silchar (2012 - till date)

XXX. Chancellor’s Nominee for the Court of Kalyani University (2017 - till date)

Awards

Sir J. C. Bose National Fellowship by Department of Science and Technology, Govt. of India (2010-2016)

Dr. P. C. Sengupta Memorial Oration Gold Medal by Calcutta School of Tropical Medicine for outstanding contribution in Kala-azar research-2004.

Prof. Jnan Chandra Ghosh Memorial Award by Science Association of Bengal for excellent contribution in the field of science & technology, research promotion and development in India and abroad in 2007.

Prof. B. K. Bachhawat Memorial Lecture Award by National Academy of Sciences, India in 2007.

Desh Ratna Dr. Rajendra Prasad Memorial Lecture Award by Rajendra Memorial Research Institute, ICMR, Patna, 2008.

Nitya Anand Endowment Lecture Award for outstanding work in Biomedical Research including New Drug Development by Indian National Science Academy (INSA) , 2012

Sir Ronald Ross Memorial 57th Foundation Day Oration Lecture Award of Institute of Post Graduate Medical Education and Research (IPGMER), Kolkata, January 2013.

Publication

1

Majumder, H.K. and Mandal, R.K. (1976) Changing pattern of RNA synthesis and its control by levels of multiple RNA polymerases in phytohemagglutinin stimulated lymphocytes. Ind. J. Biochem. Biophys. 33, 132-136.

2

Chakraborty, P.R., Salvo, R.A., Majumder, H.K. and Maitra. U. (1977) Further characterization of bacteriophage induced RNA polymerase. Studies on the size of in vitro transcripts and interaction of T3 RNA polymerase with T3 DNA. J.Biol. Chem. 252, 6485-6493.

3

Majumder, H.K., Bishayee, S., Chakraborty, P.R. and Maitra, U. (1977) RNase III cleavage of bacteriophage T3 RNA polymerase transcripts. Proc. Natl. Acad. Sci. U.S.A. , 74, 4891-4894.

4

Majumder, H.K., Maitra, U. and Rosenberg, M. (1979) Termination of transcription of transcription by bacteriophge T3 RNA polymerase. Proc. Natl. Acad. Sci. U.S.A. 76, 5110-5113.

5

Maitra, U. , Jelinek, W. Yudelevich ,A. , Majumder, H.K. and Guha, A. (1980) Isolation and sequence determination of 5’- terminal oligonucleotidefragments of RNA transcripts synthesized by bacteriophage T3 RNA polymerase from DNA. Proc. Natl. Acad. Sci. U.S.A. 77, 3908-3911.

6

Majumder, H.K. and Weber, H. (1981) 3’- terminal homology of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei. Experientia. 36, 652.

7

Majumder, H. K. , Boothryod, J.C. and Weber, H.(1981) Homologous 3’-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei .Nucl. Acids Res. 9, 4745-4753.

8

Van der Ploeg, L.H.T. , Liu, A.Y.C. , Michels, P. , De Lange, T. , Borst, P. , Majumder, H.K. , Weber, H. and Van Boom , J. (1982) Splicing is required to make mRNAs for a variant surface antigens in Trypanosomes. Nucl. Acids Res. 10, 3591-3604.

9

Datta, A. and Majumder, H.K. (1986) Effect of monosaccharides on uptake of Leishmania donovani promastigotes by murine macrophages. Ind. J. Biochem. Biophys. 23, 1-4.

10

Das Gupta, S., Adhya, S. and Majumder, H.K. (1986) A simple procedure for the prepation of pure kinetoplast DNAnet work free of nuclear DNA from kinetoplast hemoflagellate Leishmania donovani. Anal. Biochem. 158, 189-194.

11

Majumder, H.K. Adhya, S. and Maitra, U. (1987) Generation of bacteriophage T3 mRNAs by post transcriptional processing by RNase III. J.Biosci. 11, 155-166.

12

Chakraborty, A. and Majumder, H.K. (1987) Decatenation of kDNA by an ATP dependent DNA topoisomerase of kinetoplast hemoflagellate Leishmania donovani. Mol. Biochem. Parasitol. 26, 215-224.

13

Chakraborty, A. and Majumder, H.K. (1988) Mode of action of pentavalent antimonials : Specific inhibition of type DNA topoisomerase of Leishmania donovani. Biochem. Biophys. Res. Commun. 152, 605-611.

14

Das gupta, S. and Majumder, H.K. (1988) Physical characterisation of kinetoplast DNA of an indian strain of Leishmania donovani the causative agent of visceral leishmaniasis. Ind. J. Biochem. Biophys. 25, 548-553.

15

Das gupta,S. and Majumder, H.K. (1989) Sequence heterogeneity of kDNA minicircles of Leishmania donovani an Indian strain of visceral leishmaniasis. J.Cell. Biochem. 13D, 142.

16

Das gupta, S., Ghosh, D.K. and Majumder, H.K. (1991) A cloned kDNA minicircle fragment from a Leishmania spp. specific for post kala- azar dermal leishmaniasis. Parasitology 102, 187-191.

17

Chakraborty, A.K. and Majumder, H.K. (1991) An ATP dependent DNA topoisomerase from kinetoplast hemoflagellate Leishmania donovani. Biochem. Biophys. Res. Commun. 180, 279-285.

18

Chakraborty, A.K., Gupta, A. and Majumder, H.K. (1993) A type I DNA topoisomerase from kinetoplastid hemoflagellated protozoan parasite Leishmania donovani. Ind. J. Biochem. Biophys. 30, 257-262.

19

Bhattachryya, R., Singh, R., Hazra, T.K. and Majumder, H.K. (1993) Application of polymerase chain reaction with specific and arbitrary primers in identification and diferrentiation of Leishmania parasites. FEMS Microbiol. Letts. 114, 99-104.

20

Singh, R., Dutta, C. and Majumder, H.K. (1994) Analysis of sequences of two different classes of kDNA minicircles of a Leishmania spp. J.Biosci. 19, 171-182.

21

Nair, T.M., Madhusudan, K., Nagraja, V. Majumder, H.K. and Singh, R. (1994) On the mobility behavior of a curved DNA ragment located in circularpermutations. FEBS Letts. 351, 321-324.

22

Singh,R., Siddiqui, K.A.I. , Valenzuela, M.S. and Majumder, H.K. (1995) Kinetoplast DNA minicircle binding proteins in a Leishmania spp: Interference of protein -DNA interaction by berenil. Ind. J. Biochem. Biophys. 32, 437-441.

23

Bhattacharyya, R., Das, K., Sen, S., Ray, S. and Majumder, H.K. (1996) Development of a genus specific primer set for detection of Leishmania parasites by PCR. FEMS Microbiol. Letts. 135, 195-200.

24

Ray, S., Majumder, H.K., Mukhopadhyay, S., Gil, R.R. and Cordell, G.A. (1996) Amarogentin, a naturally occurring seco iridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani. J.Natl. Prod. 59, 27-29.

25

Sen, S., Khalkho, N.V.M. and Majumder, H.K. (1996) DNA polymerase from parasite protozoa Leishmania donovani UR6: Evidence of the presence of a novel kind of DNA polymerase. Biochem. Biophys. Res. Commun. 221, 662-669.

26

Nair, T.M., Madhusudan, K., Nagraja, V., Kulkarni, B.D., Majumder, H.K. and Singh, R.(1996) Theoretical permutation gel electrophoretic analysis of a curved DNAfragment located in a circular permutation. Electrophoresis. 17, 633-641.

27

Ray, S., Sadhukhan, P.K., Mandal, N.B., Mahato, S.B. and Majumder, H.K. (1997) Dual inhibition of DNA topoisomerases of Leishmania donovani by novel indolyl quinolines. Biochem. Biophys. Res. Commun. 230, 171-175.

28

Sadhukhan, P.K., Chakraborty, A.K., Das gupta, A. and Majumder, H.K. (1997) Chromatographic separation of DNA dependent RNA polymerases and Molecular properties of RNA polymerase II from a Leishmania spp. Mol. Cell. Biochem. 171,105-114.

29

Mukhopadhyay, S., Sen, P., Majumder, H.K. and Roy, S. (1998) Reduced expression of lipophosphoglycan (LPG) and kinetoplastid membrane protein (KMP-11)in Leishmania donovani promastigotes in axenic culture. J. Parasitol. 84, 644-647.

30

Ray, S., Hazra, B., Mittra, B., Das, A. and Majumder, H.K. (1998) Diospyrin, a bis- naphthoquinone: A novel inhibitor of type DNA topoisomerase of Leishmania. Mol. Pharmacol. 54, 994-999.

31

Mittra, B., Sadhukhan, P.K. and Majumder, H.K. (1998). A novel endonuclease from kinetoplastid hemoflagellateed protozoan parasite Leishmania donovani. J.Biochem. 124, 1198-1205.

32

Mittra,B., Saha,A., RoyChowhury,A., Pal,C., Mandal,S., Mukhopadhyay,S., Bandyopadhyay,S. and Majumder,H.K. (2000) Luteolin, an abundant dietary component is a potent antileishmanial agent that acts by inducing topoII mediated kinetoplast DNA cleavage leading to apoptosis. Molecular Medicine. 6,527-541.

33

Das, A., Dasgupta, A., Sharma, S., Sengupta, T., Ghosh, M., Bandyopadhyay, S. and Majumder H., K. (2001) Characterization of the gene encoding type II DNA topoisomerase from Leishmania donovani: a key molecular target in anti leishmanial therapy. Nucleic Acids Res. 29, 1844-1851.

34

Das, A., Mandal, C., Dasgupta, A., Sengupta, T. and Majumder, H.K. (2002) An insight in to the active site of a type I DNA topoisomerase from the kinetoplastid protozoan Leishmania donovani. Nucleic Acids Res. 30, 794-802.

35

Dasgupta, A., Sharma, S., Das, A., Sarkar, D. and Majumder, H.K. (2002) Carboxy terminal domain of largest subunit of RNA polymerase II of Leishmania donovani has unusually low number of phosphorylation sites. Medical Science Monitor. 8, CR341-50.

36

Roy Chowdhury ,A., Mandal, S., Mittra, B., Sharma, S., Mukhopadhyay, S. and Majumder, H.K. ( 2002) Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: Identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Medical Science Monitor. 8, BR254-65.

37

Chowdhury A. R., Sharma, S., Mandal, S., Goswami, Mukhopadhyay, S. and Majumder, H. K. (2002) Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem. J. 366, 653-661.

38

Chowdhury A. R., Mandal, S., Goswami, A., Ghosh, M., Mandal, L., Chakraborty, D., Ganguly, A., Tripathi, G., Mukhopadhyay, S., Bandyopadhyay, S. and Majumder, H. K. (2003) Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA toposiomerase I and II: implications in antileishmanial therapy. Mol. Med. 9, 26-36.

39

Sengupta, T., Mukherjee, M., Mandal, C. N., Das, A. and Majumder, H. K. (2003) Functional dissection of the C-terminal domain of type II DNA Topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani. Nucleic Acids Res. 31, 5305-5316.

40

Das, B. B., Sen, N., Ganguly, A. and Majumder, H. K. (2004) Reconstitution and functional characterization of the unusual bisubunit type I DNA Topoisomerase from Leishmania donovani. FEBS.Letts. 565, 81-88.

41

Sen, N., Das, B. B., Ganguly, A., Mukherjee, T., Tripathi, G., Bandopadhyay, S., Rakshit, S., Sen, T. and Majumder, H. K. (2004) Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death & Differentiation. 11, 924-936.

42

Sen, N., Das, B. B., Ganguly, A., Mukherjee, T., Bandopadhyay, S., Majumder, H. K. (2004) Camptothecin-induced imbalance in intracellular cation homeostasis regulates programmed cell death in unicellular hemoflagellate Leishmania donovani. J Biol Chem. 279, 52366-75.

43

Pal, S., Aggarwal, G., Haldar, A., Majumdar, A., Majumder, H. K. and Duttagupta, S (2004) Diagnosis of symptomatic kala-azar by polymerase chain reaction using patient's blood. Med. Sci. Monit. 10(1), MT1-5

44

Manna, M., Majumder, H. K., Sundar, S. and Bhaduri, A. N. (2005) The molecular characterization of clinical isolates from Indian Kala-azar patients by MLEE and RAPD-PCR. Med. Sci. Monit. 11(7), BR220-7.

45

Das, B.B., Sen, N., Dasgupta, S. B., Ganguly, A., Majumder, H. K. (2005) N-terminal region of the large subunit of Leishmania donovani bi-subunit Topoisomerase I is involved in DNA relaxation and interaction with smaller subunit. J. Biol. Chem. 280(16), 16335-44.

46

Sengupta, T., Mukherjee, M., Das, R., Das, A. and Majumder, H. K. (2005) Characterisation of the DNA-binding domain and identification of the active site residue in the ‘Gyr a’ half of Leishmania donovani topoisomerase II. Nucleic Acids Res. 33,2364-2373.

47

Sengupta, T., Mukherjee, M., Das, A., Mandal, C., Das, R., Mukherjee, T. and Majumder, H. K. (2005) Characterisation of the ATPase activity of Toposiomerase II from L. donovani and identification of residues conferring resistance to etoposide. Biochem.J.390,419-26.

48

Ganguly, A., Das, B. B., Sen, N., Roy, A., Bose Dasgupta, S and Majumder, H. K. (2006) ‘Leish Man’ topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani. Nucleic Acids Res. 34(21), 6286-97.

49

Das, B. B., Sen, N., Bose Dasgupta, S., Ganguly, A., Das, R. and Majumder, H. K. (2006) Topoisomerase research of kinetoplastid parasite Leishmania, with special reference to development of therapeutics. Indian J. Med. Res. 123, 221-232.

50

Sen N, Das BB, Ganguly A, Banerjee B, Sen T, Majumder HK (2006) Leishmania donovani: intracellular ATP level regulates apoptosis-like death in luteolin induced dyskinetoplastid cells. Exp Parasitol. 114(3):204-14.

51

Das BB, Sen N, Roy A, Dasgupta SB, Ganguly A, Mohanta BC, Dinda B, Majumder HK (2006) Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I. Nucleic Acids Res. 34(4):1121-32.

52

Chaudhuri, P., Majumder, HK. and Bhattacharya S (2007) Synthesis, DNA binding, and Leishmania topoisomerase inhibition activities of a novel series of anthra[1,2-d]imidazole-6,11-dione derivatives. J Med Chem. 17;50(10):2536-40.

53

Das BB, Bose Dasgupta S, Ganguly A, Mazumder S, Roy A, Majumder HK (2007) Leishmania donovani bi subunit topoisomerase I gene fusion leads to an active enzyme with conserved type IB enzyme function FEBS J 274(1):150-63.

54

Sen. N., Banerjee, B., Das, B. B., Ganguly, A., Sen, T., Pramanik, S., Mukhopadhyay, S. and Majumder, H. K. (2007) Apoptosis is induced in leishmanial cells by a novel Protein Kinase Inhibitor Withaferin A and is facilitated by Apoptotic Topoisomerase I DNA Complex. Cell Death & Differ. Cell Death Differ, 14(2):358-67.

55

Sen. N., Banerjee, B., B. B., Ganguly, A., Sen, T., Pramanik, S., Mukhopadhyay, S. and Majumder, H. K. (2007) Leishmania donovani. Dyskinetoplastid cells survive and proliferate in the presence of pyruvate and uridine but do not undergo apoptosis after treatment with camptothecin. Experimental Parasitol 115(2):215-9.

56

Bosedasgupta S., Das BB., Sengupta, S., Ganguly, A., Tripathi, G and Majumder, HK (2007) Amino acids 39-456 of large subunit and 210-262 of small subunit constitute the minimal, functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania. Biochem J. 409(2):481-9.

57

Bosedasgupta S., Das BB., Sengupta, S., Ganguly, A., Tripathi, G and Majumder, HK (2007) Amino acids 39-456 of large subunit and 210-262 of small subunit constitute the minimal, functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania. Biochem J. 409(2):481-9.

58

Bosedasgupta S., Ganguly, A., Roy A., Mukherjee, T. and Majumer, HK (2007) A novel ATP-binding cassette transporter, ABCG6 is involved in chemoresistance of Leishmania. Mol. Biochem Parasitol 158(2):176-88.

59

Ganguly A, Das B, Roy A, Sen N, Dasgupta SB, Mukhopadhayay S, Majumder HK (2007) Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death. Cancer Res. 67(24):11848-58.

60

BoseDasgupta S, Ganguly A, Das BB, Roy A, Khalkho NV, Majumder HK.(2008) The large subunit of Leishmania topoisomerase I functions as the 'molecular steer' in type IB topoisomerase. Mol. Microbial. 67(1):31-46.

61

Bosedasgupta S, Das BB, Sengupta S, Ganguly A, Roy A, Dey S, Tripathi G, Dinda B, Majumder HK (2008) The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFEN-1 and LdTatD as a DNA 'degradesome'. Cell. Death & Differ 15(10):1629-40.

62

Das R, Roy A, Dutta N, Majumder HK (2008) Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani. Apoptosis 13(7):867-82.

63

Misra P, Khaliq T, Dixit A, SenGupta S, Samant M, Kumari S, Kumar A, Kushawaha PK, Majumder HK, Saxena AK, Narender T, Dube AMisra P, Khaliq T, Dixit A, SenGupta S, Samant M, Kumari S, Kumar A, Kushawaha PK, Majumder HK, Saxena AK, Narender T, Dube A (2008) Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug designAntileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design. J Antimicrob Chemother.62(5):998-1002.

64

Roy, A., Das, B. B., Ganguly, A., BoseDasgupta, S., Khalkho, N.V.M., Pal, C., Dey, S., Giri, VS., Jaisankar, P., Dey, S. and Majumder, HK (2008). An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3-3’-di-indolylmethane, novel DNA topoisomerase I poison with a strong binding affinity to the enzyme Biochem. 409, 611-3-622.

65

Roy, A, Ganguly, A., BoseDasgupta, S., Das, B. B., Pal, C., Jaisankar, P. and Majumder, HK (2008) Mitochondria-Dependent reactive oxygen species-mediated programmed cell death induced by 3,3’-Diinodlylmethane through inhibition of FOF1-ATP Synthase in Unicellular Protozoan Parasite Leishmania donovani. Mol. Pharmacol. 74, 1292-1307.

66

Pramanick S, Roy A, Ghosh S, Majumder HK, Mukhopadhyay S (2008) Withanolide Z, a New Chlorinated Withanolide from Withania somnifera. Planta Med 74(14), 1745-8.

67

Ganguly, A; Sengupta, S., BoseDasgupta, S, Roy, A. and Majumder, H. K. (2009) Mutational studies reveal lysine 352 on the large subunit is indispensable for catalytic activity of bi-subunit topoisomerase I from Leishmania donovani. Mol. & Biochemical Parasitology 165, 57-66

68

Roy A, Bosedasgupta S, Ganguly A, Jaisankar P, Majumder HK (2009) Topoisomerase I gene mutations at F270 in the large subunit and at N184 in the small subunit contribute to the resistance mechanism of unicellular parasite Leishmania donovani towards 3,3'-Diindolylmethane (DIM) Antimicrob Agents Chemother 53(6):2589-98.

69

Castelli S, Campagna A, Vassallo O, Tesauro C, Fiorani P, Tagliatesta P, Oteri F, Falconi M, Majumder HK, Desideri (2009) A Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin Arch Biochem Biophys. 486(2):103-10.

70

Misra P, Sashidhara KV, Singh SP, Kumar A, Gupta R, Chaudhaery SS, Gupta SS, Majumder HK, Saxena AK, Dube A (2010) 16alpha-Hydroxycleroda-3,13 (14)Z-dien-15,16-olide from Polyalthia longifolia: a safe and orally active antileishmanial agent. Br J Pharmacol. 159(5):1143-50.

71

Coletta A, Morozzo della Rocca B, Jaisankar P, Majumder HK, Chillemi G, Sanna N, Desideri A (2010) Assignment of UV-vis spectrum of (3,3')-diindolylmethane, a Leishmania donovani topoisomerase IB inhibitor and a candidate DNA minor groove binder. J Phys Chem A. 114(26):7121-6.

72

Banerjee B, Roy A, Sen N, Majumder HK (2010) A tyrosyl DNA phosphodiesterase 1 from kinetoplastid parasite Leishmania donovani (LdTdp1) capable of removing topo I-DNA covalent complexes. Mol. Microbiol. 78(1):119-3.

73

Sengupta S, Ganguly A, Roy A, Bosedasgupta S, D'Annessa I, Desideri A, Majumder HK. (2010) ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism. Nucleic Acids Res. [Epub ahead of print].

74

Sengupta, S; Chowdhury, S; BoseDasgupta, S; Wright, C. W. And Majumder, H. K. (2011) Crytolepine-Induced Cell Death of Leishmania donovani Promastigotes is augmented by inhibition of autophagy. Mol. Bio. Int. 2011:185413.

75

Chowdhury S, Mukherjee T, Sengupta S, Chowdhury SR, Mukhopadhyay S, Majumder HK (2011) Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase. Mol Pharmacol. 80:694-703.

76

Roy A, Chowdhury S, Sengupta S, Mandal M, Jaisankar P, D'Annessa I, Desideri A, Majumder HK (2011) Development of derivatives of 3, 3'-diindolylmethane as potent Leishmania donovani bi-subunit topoisomerase IB poisons. PLoS One. 6:e28493.

77

Banerjee B, Sen N, Majumder HK (2011) Identification of a Functional Type IA Topoisomerase, LdTopIIIβ, from Kinetoplastid Parasite Leishmania donovani. Enzyme Res. 2011:230542.

78

Banerjee B, Sen N, Majumder HK (2011) Identification of a Functional Type IA Topoisomerase, LdTopIIIβ, from Kinetoplastid Parasite Leishmania donovani. Enzyme Res 2011:230542.

79

Sengupta S, Chowdhury S, Bosedasgupta S, Wright CW, Majumder HK (2011) Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy. Mol Biol Int 2011:187850.

80

Chowdhury S, Mukherjee T, Mukhopadhyay R, Mukherjee B, Sengupta S, Chattopadhyay S, Jaisankar P, Roy S and Majumder HK (2012) Niranthin, a Lignan, intercepts Leishmania donovani replication by poisoning topoisomerase IB of parasite and ameliorates Th1 response to cure infected-BALB/c mice. EMBO Mol Med 4:1126-43.

81

Saha S, Mukherjee T, Chowdhury S, Mishra A, Chowdhury SR, Jaisankar P, Mukhopadhyay S and Majumder HK (2013) The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo. Biochem Pharmacol. 86:1673-87.

82

Das BB, Huang SY, Murai J, Rehman I, Amé JC, Sengupta S, Das SK, Majumdar P, Zhang H, Biard D, Majumder HK, Schreiber V and Pommier Y (2014) PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage. Nucleic Acids Res. 42:4435-49.

83

Chowdhury S, Mukherjee T, Chowdhury SR, Sengupta S, Mukhopadhyay S, Jaisankar P and Majumder HK (2014) Disuccinyl Betulin Triggers Metacaspase-Dependent Endonuclease G-Mediated Cell Death in Unicellular Protozoan Parasite Leishmania donovani. Antimicrob Agents Chemother. 58:2186-201.

84

Chowdhury S, Mukhopadhyay R, Saha S, Mishra A, Sengupta S, Roy S, Majumder HK (2014) Flavone resistant Leishmania donovani over expresses LdMRP2 transporter in the parasite and activates host MRP2 on macrophages to circumvent the flavone-mediated cell death. J Biol Chem. 6;289(23):16129-16147.

85

Das P, Jain CK, Dey SK, Saha R, Dutta Chowdhury A, Roychoudhury S, Kumar S, Majumder HK and Das S (2014) Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(II) complex of purpurin: dual poison for human DNA topoisomerase I and II. Royal Soc Chem Adv 4: 59344–57

86

Mishra A, Vinayagam J, Saha S, Chowdhury S, Roychowdhury S, Jaisankar P, Majumder HK (2014) Isobenzofuranone derivatives exhibit antileishmanial effect by inhibiting type II DNA topoisomerase and inducing host response. Pharmacol Res Perspect 2(6): e00070. doi: 10.1002/prp2.70

87

Chakraborty D, Maity A, Jain CK, Hazra A, Bharitkar YP, Jha T, Majumder HK, Roychoudhury S and Mondal NB (2015) Cytotoxic potential of dispirooxindolo/acenaphthoquino andrographolide derivatives against MCF-7 cell line. Med Chem Commun 6:702

88

Jain CK, Pradhan BS, Banerjee S, Mondal NB, Majumder SS, Bhattacharyya M, Chakrabarti S, Roychoudhury S, Majumder HK (2015) Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo. Nat Sci Rep. 5, 12082, doi:10.1038/srep12082).

89

Jain CK, Roychoudhury S, Majumder HK (2015) Selective killing of G2 decatenation checkpoint defective colon cancer cells by catalytic topoisomerase II inhibitor. Biochim Biophys Acta. 1853(5): 1195-204.

90

Kumar A, Chowdhury SR, Sarkar T, Chakrabarti T, Majumder HK, Jha T, Mukhopadhyay S (2016) A new bisbenzylisoquinoline alkaloid isolated from Thalictrum foliolosum, as a potent inhibitor of DNA topoisomerase IB of Leishmania donovani. Fitoterapia. 109: 25-30.

91

Mamidala R, Majumdar P, Jha KK, Bathula C, Agarwal R, Chary MT, Majumder HK, Munshi P, Sen S (2016) Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors. Nat Sci Rep. 6:28120. doi: 10.1038/srep28120.

92

Saha S, Acharya C, Pal U, Chowdhury SR, Sarkar K, Maiti NC, Jaisankar P, Majumder HK (2016) A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB Topoisomerase. Animicrob Agents Chemother. 60(10): 6281-93.

93

Singh MK, Bhaumik SK, Karmakar S, Paul J, Sawoo S, Majumder HK, Roy A (2017) Copper salisylaldoxime (CuSAL) imparts protective efficacy against visceral leishmaniasis by targeting Leishmania donovani topoisomerase IB. Exp Parasitol. 175: 8-20.

94

Chowdhury SR, Kumar A, Godinho JLP, De Macedo Silva ST, Zuma AA, Saha S, Kumari N, Rodrigues JCF, Sundar S, Dujardin JC, Roy S, De Souza W, Mukhopadhyay S, Majumder HK (2017) Voacamine alters Leishmania ultrastructure and kills parasite by poisoning unusual bi-subunit topoisomerase IB. Biochem Pharmacol. 138:19-30.

Scientific Reviews

1

1. Mandal, R.K., Ganguly, A. and Majumder, H.K. (1974) Biology and Biochemistry of chromatin . J.Sci. Ind. Res. 33, 533-543.

2

2. Majumder, H.K. (1996) Molecular Biology of Leishmania. Proc. Natl. Acad. Sci. (India). 66, 205-224.

3

3. Chakraborty, A. K. and Majumder, H.K. (1999) Molecular Biology of Leishmania : Kinetoplast DNA and DNA topoisomerases as novel therapeutic targets. Curr. Sci. 76, 1462-1472.

4

4. Das, A., Sengupta, T., Dasgupta, A and Majumder, H. K. (2004) Toppisomerases of kinetoplastid parasites as potential chemotherapeutic targets. Trends in Parasitol, 20 (8), 381-387.

5

5. Chowdhury, A. R., Majumder, H. K. (2004) DNA Topoisomerases in Life and Death; Implications in kinetoplastid protozoa. Curr Mol. Med. 4(6):711-22.

6

6. Mukherjee, M., Sengupta, T. and Majumder, H. K. (2005) Biochemistry of Leishmania Parasites in relation to developing rational approaches to chemotherapy. Proceedings of the Indian National Science Academy (PINSA-B). B70(5&6), 579-591.

7

7. Das, B. B., Sengupta, T., Ganguly, A. and Majumder, H. K. (2006) Topoisomerases of kinetoplastid parasites;why so fascinating?. Mol. Microbial. 62, 917-27.

8

8. Das, BB., Ganguly, A. and Majumder, HK (2008) DNA topoisomerases of Leishmania: the potential targets for anti-leishmanial therapy. Adv Exp Med Biol 625:103-15.

9

9. Sen, N and Majumder HK (2008) Mitochondrion of protozoan emerges as potent therapeutic target: exciting drugs are on the horizon. Current Pharm. Design. 14(9):839-46.

10

10. Jain CK, Majumder HK, Roychoudhury S (2017) Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases. Curr Genomics. 18(1): 75-92.

Books Edited



1. Executive Editor of a special issue the Journal of Current Molecular Medicine. Topic of the special issue: Biology and Biochemistry of the Kinetoplastid Parasites Vol. 4, Issue 6, September 2004. Publisher: Bentham Science Publishers, USA


2. Executive Editor of the special issue entitled Drug Targets in Kinetoplastid Parasites, of the book Advances in Experimental Medicine and Biology Vol. 625 published by Landes Biosciences Publishers, USA (Published online), December, 2007.


3. Edited Special Issue entitled Target Identification and Intervention Strategies against Kinetoplastid Protozoan Parisites, of the journal Molecular Biology International year 2011. Guest Editors: Hemanta K. Majumder, Wanderley De Souza and Kwang Poo Chang.


4. Editor of the book entitled Molecular Biology of Kinetoplastid Parasites, published by Caister Academic Press, Norfolk, UK (2017)


Chapters in books:


Das, B. B., Ganguly, A. and Majumder, H. K. (2007) DNA Topoisomerases of Leishmania:The Potential Targets for Anti-Leishmanial Therapy. In Drug Targets in Kinetoplastid Parasites, (Advances in Experimental Biology and Medicine) Ed. By H.K. Majumder, Landes Biosciences Publishers, USA


Sen, N., Banerjee, B. and Majumder, H. K. (2007) Molecular Analysis of Programmed Cell Death by DNA Topoisomerase inhibitors in Kinetoplastid Parasite Leishmania in Programmed Cell Death in Protozoa Ed. by Jose Manuel Perez Martin, Landes Biosceinces & Springer Science Publishers, USA.


Saha, S., Chowdhury, S.R. and Majumder, H. K. (2017) DNA Topoisomerases of Kinetoplastid Parasites: Brief Overview and Recent Perspectives. In Molecular Biology of Kinetoplastid Parasites. Ed. By H. K. Majumder, Caister Academic Press, Norfolk, UK


Ph. D Thesis guided by Dr. H. K. Majumder

Sl. No. Year of Award Name Title of the thesis University
01 1988 Dr. Srimita Dasgupta Molecular biological studies on the structure and function of the kinetoplast DNA of the protozoan parasite Leishmania donovani Calcutta University
02 1988 Dr. Asit Kumar Chakraborty Molecular biological studies on kinetoplastid hemoflagellate Leishmania donovani with reference to the enzymes involved in nucleic acid metabolism Calcutta University
03 1992 Dr. Ashim Gupta Molecular Biological studies on L-Gulonolactone oxidase, a key enzyme in ascorbic acid biosynthesis Jadavpur University
04 1993 Dr. Rajan Singh Structure and sequence organization of mincircles of kinetoplast DNA network in hemoflagellated protozoan parasite Leishmania spp. Jadavpur University
05 1995 DR. Pranab Kr. Sadhukhan Molecular Biological studies of RNA Polymerase(s) of kinetoplastid Hemoflagellated protozoan parasite Leishmania Jadavpur University
06 1996 Dr. Ridddhi Bhattacharyya The kinetoplast DNA of haemoflagellated protozoan parasite Leishmania: Application in strain identification and differentiation Jadavpur University
07 1997 Dr. Sutapa Roy Molecular Biological studies on DNA topoisomerases from kinetoplastid haemoflagellated protozoan parasite Leishmania Jadavpur University
08 1999 Dr. Bidyottam Mittra Molecular Biological studies of an endonuclease and DNA topoisomerases from the kinetoplastid parasite Leishmania Jadavpur University
09 1999 Dr. Arindam Dasgupta Molecular characterization of RNA polymerase II largest subunit gene and DNA topoisomerase I gene from Leishmania donovani Jadavpur University
10 2001 Dr. Aditi Das Molecular Cloning and Biochemical characterization of DNA topoisomerases from Leishmania donovani Jadavpur University
11 2002 Dr. Arnab Roy Chowdhury DNA topoisomerase: Targets for therapeutic agents Jadavpur University
12 2005 Dr. Tanushri Sengupta Functional domain organization and characterization of type II DNA topoisomerase of kinetoplastid hemoflagellate protozoan parasite Leishmania donovani Jadavpur University
13 2005 Dr. Benu Brata Das Molecular Characterization of the structure of DNA topoisomerase I gene of Leishmania donovani Jadavpur University
14 2006 Dr. Nilkantha Sen Inhibitors of DNA toposiomerases: The potent antileishmanial agents induce programmed cell death in Leishmania donovani Jadavpur University
15 2008 Dr. Agneyo Ganguly Structural and Functional studies of eukaryotic topoisomerase I with special reference to Leishmania donovani type I DNA topoisomerase Jadavpur University
16 2088 Dr. Rakhee Das Leishmania donovani DNA topoisomerases I and II: Molecular Biological studies in relation to their mode of action Jadavpur University
17 2008 Dr. Somdeb Bose Dasgupta Mechanistic studies of the unusual properties inherent to Topoisomerase I of Leishmania donovani Jadavpur University
18 2010 Dr. Amit Roy Inhibition of Eukaryotic DNA Topoisomerase I: Understanding the Mechanisms of Cell Death And Drug Resistance Jadavpur University
19 2010 Ms. Bijoylaxmi Banerjee Molecular and Biochemical Characterization of DNA Topoisomerases and Repair Enzymes from Leishmania donovani towards search for plausible therapeutic targets Jadavpur University
20 2012 Mr. Souvik Sengupta DNA toposiomerases of Leishmania: Modulation of functional activity and drug induced cell killing of the parasite Jadavpur University
21 2012 Mrs. Neeta VM Khalkho Molecular cloning and biochemical characterization of universal minicircle sequence binding protein (UMSBP) from unicellular flagellate kinetoplastid protozoan parasite Leishmania donovani Jadavpur University
22 2014 Mr. Sayan Chowdhury Development of Inhibitors of DNA Topoisomerase(s) of Leishmania donovani with Potent Antileishmanial Activities and Study on the Mechanism of Drug Resistance. University of Calcutta
23 2015 Mr. Chetan Kumar Jain DNA topoisomerases and their interacting proteins as targets for development of therapeutics in cancer University of Calcutta
24 2016 Mr. Sourav Saha DNA topoisomerase(s) of Leishmania donovani and development of Inhibitors with potent antileishmanial activities University of Calcutta
25 Ongoing Mr. Somenath Roy Chowdhury Targeting topoisomerase(s) for anti- leishmanial chemotherapy and understanding the mechanism of topoisomerase related DNA damage repair machineries in Leishmania donovani University of Calcutta

Contact Me

Address

Office

Hemanta K. Majumder
CSIR- Indian Institute of Chemical Biology
4, Raja S.C. Mullick Road
Jadavpur

Kolkata- 700 032, INDIA.

Residence

Digantika Samabaya Abasani
Flat- F/11,
Block- AH,
Sector-II Salt Lake City

Kolkata- 700 091, INDIA.

Phone No

91-33-9831926491 ( Mobile)
91-33-23591532 ( Res)
91-33-24995727 ( Off)

Email

hemantamajumder@yahoo.co.in
hkmajumder@iicb.res.in